SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


Main Search Enzymes Substrates Ubiquitination types BLAST Feedback HELP

Wild-type Information
Standard nameSEC61
Systematic nameYLR378C
Alias
DescriptionProtein transport protein SEC61
Cross references Swiss-Prot accessionP32915
SGD YLR378C

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1   HECT RSP5   
2  UBC6, UBC7RINGSPRFHRD1  Proteasomal degradation
* Blank: not determined, NA: not applicable.

References
[1]Evidence 
Method 
Reference"An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport."
Haynes CM, Caldwell S, Cooper AA.
J Cell Biol. 158(1):91-101 (2002) [12105183]
[2]Evidence 
Method 
Reference"Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins."
Bordallo J, Plemper RK, Finger A, Wolf DH.
Mol Biol Cell. 9(1):209-22 (1998) [9437001]