SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Wild-type Information
Standard namePRC1
Systematic nameYMR297W
AliasLBC1
DescriptionCarboxypeptidase Y [Precursor]
Cross references Swiss-Prot accessionP00729
SGD YMR297W

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1  UBC4, UBC5HECT RSP5   
2 MULTIUBC1, UBC6, UBC7RINGSPRFHRD1  Proteasomal degradation
* Blank: not determined, NA: not applicable.

References
[1]Evidence 
Method 
Reference"An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport."
Haynes CM, Caldwell S, Cooper AA.
J Cell Biol. 158(1):91-101 (2002) [12105183]
[2]Evidence 
Method 
Reference"Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins."
Bordallo J, Plemper RK, Finger A, Wolf DH.
Mol Biol Cell. 9(1):209-22 (1998) [9437001]

"Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome."
Plemper RK, Wolf DH.
Mol Biol Rep. 26(1-2):125-30 (1999) [10363658]

"Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation."
Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY.
Nat Cell Biol. 3(1):24-9 (2001) [11146622]

"Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD."
Taxis C, Hitt R, Park SH, Deak PM, Kostova Z, Wolf DH.
J Biol Chem. 278(38):35903-13 (2003) [12847107]