SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameUFO1
Systematic nameYML088W
DescriptionF-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation.

Ubiquitination Features
Num. of substrates Total 3 wild-type known substrates.
Wild-type substrate
KeywordDescription
HOHomothallic switching endonuclease
RAD30DNA polymerase eta
UFO1Ubiquitin ligase complex F-box protein UFO1

Cross References
Swiss-Prot accessionQ04511
SGD YML088W
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Cellular componentGO:0005634nucleusIDA:SGD.
Cellular componentGO:0019005SCF ubiquitin ligase complexIPI:SGD.
Molecular functionGO:0005515protein bindingIDA:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIMP:SGD.
Biological processGO:0006974response to DNA damage stimulusIMP:SGD.
Biological processGO:0006511ubiquitin-dependent protein catabolic processIMP:SGD.
EC number

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length668
Molecular weight76860

	---------+----------+----------+----------+----------+
MERPGLVLQD LPPEILINIF SHLDEKDLFT LQELSTHFRN LIHDEELWKN   50
LFKSRVHTTH FPTFSQSSKF SVEYIERTRG LHHWQHNKAI RTKYTIIPTR   100
NWDQPSIERI VFDYPRVAAY NDGTITILQL QNHKRQKKFK KLIYIPCTTP   150
QGCSTMDFNI NAAVFGRFDG RVFGKLLSNK SYLTPVMEFT GRHSAGVTAI   200
CNSESWDTSR EDWSVSGSEN GEIIWWCENK LVKMWKVSNR VIWKLAFFKD   250
WTLIMDDEKL YIIHQMQELH SIDIPKDLDE QPMRVRFFKM DFGSMTLVLA   300
DLNNVYTISV NPNGNFGNLR KLEMPEQICA VEIDEKTSQR EQNWQFAGDD   350
GCYISLLTTQ NTLYIINIRD LSSSGLKVQC KISFDEQVYV SQVTNLIVVV   400
ALPNVLQILN AMTGELIKTV LKTEKFPEFL KVSQDKIIMG SGNVLNYLKF   450
VSSDSKKHHH STKGKNTVSN KWNETLNTEL QYYDEDEDLR RKRQSEISRL   500
IDAYGGDLEL SGDTDEENDI QLRIALLESQ EAQARNQAEA GEPVGDDEDE   550
QLRRALEESQ LIYETQTNSS ANHGNNTNDE IDEDDEEFLR AIRQSRVEDE   600
RRRHLRNHTT GRRNGPLSDD NFATYGAAES SERTSTENTI GSSVGVDASN   650
NVDEDLQLAI ALSLSEIN                                      668