SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameTUL1
Systematic nameYKL034W
DescriptionGolgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes.

Ubiquitination Features
Num. of substrates Total 3 wild-type known substrates.
Wild-type substrate
KeywordDescription
CPS1Carboxypeptidase S
PPN1Endopolyphosphatase
TLG1T-SNARE affecting a late Golgi compartment protein 1

Cross References
Swiss-Prot accessionP36096
SGD YKL034W
Gene Ontology (GO)
Cellular componentGO:0005794Golgi apparatusIDA:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIPI:SGD.
Biological processGO:0016567protein ubiquitinationIMP:SGD.
Biological processGO:0043162ubiquitin-dependent protein catabolic proce...IMP:SGD.
EC number 6.3.2.-

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length758
Molecular weight87880

	---------+----------+----------+----------+----------+
MEIDGNTLVF IIVILFLFFS SPGGDGVSSQ YEFNQLQRLK QQFRTEHNTF   50
VNMTYTDSFR NITGLKLSYQ DMLNNPLQNA TYPLPGKDYD RWFPNQNYMV   100
LPNDVIEAIN TEVWNTSNDD ASNLFPPNIT STLLGKIDLV SNNKYEKIRM   150
PVPRFYEPAT DFSEDIPPEG ETYWSEWPSY GELHNVSFQH GEIAIQISHM   200
SNLQDNNNYL RRNFINKKND RWKLLNLQID FSDKAEKEKH SIYSKAVYDI   250
QRGRILSISQ SSKFHSLFAL PHYMSFQNDY NEKIFNDVKE LVDEFWNFTD   300
YTDVMTMKDV QDAYNNANFK CEYLIFLQLE PWNQYTRDQI KLIDDELNWP   350
LGRPANLSSL PPINVVSGLL YSPDCGVRLG LHNVKGTRYE LKIMSIRKHL   400
LFGIALFAAQ IYLLLTQMHH TNTPSMVNKI SFYCFSMINL VDGSLATLYF   450
VAASVVPELY LPLVISAFSC FILASIFEIR YLISIYASQV NEQNVGIINL   500
LRGNTGTYDE NRPRPAFIPD EGSIGGSLYG RFFFMLIIFT FLILSSTSWP   550
RQLRMVFEYI LIFILNSYWI PQIFRNAVKG IPSRRERARS SIGGNRSQNK   600
MPLLWSFVIG TTIIRSLPVV YVFTYSSNVF RHHKDVHFVV FLSLWLLFQI   650
SILYSQDVLG SRWFLPKHTI PDGYSYFKPL SNEYISEHGG GTAEHTVDCA   700
ICMSDVPIYI EEIPETHKVD QHSYMVTPCN HVFHTSCLEN WMNYKLQCPV   750
CRSPLPPL                                                 758