SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameSAN1
Systematic nameYDR143C
DescriptionUbiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing.

Ubiquitination Features
Num. of substrates Total 1 wild-typeand 4 mutant known substrates.
Wild-type substrate
KeywordDescription
SIR4Regulatory protein SIR4
Mutant substrate
KeywordWild type description
mCDC13Cell division control protein 13
mSIR3Regulatory protein SIR3
mSIR4Regulatory protein SIR4
mSPT16FACT complex subunit SPT16

Cross References
Swiss-Prot accessionP22470
SGD YDR143C
Gene Ontology (GO)
Cellular componentGO:0005634nucleusIDA:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0006325establishment and/or maintenance of chromat...IGI:SGD.
Biological processGO:0006950response to stressIMP:SGD.
Biological processGO:0006511ubiquitin-dependent protein catabolic processIDA:SGD.
EC number

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length610
Molecular weight65618

	---------+----------+----------+----------+----------+
MSESGQEQNR GTNTSPNNAE NNNNSNAASG PLNGGAEQTR NITVSIQYSY   50
FTPERLAHLS NISNNDNNEN NSAASGSTIA NGTGPSFGIG NGGHQPDGAL   100
VLSFRDVPAS TPQDRLNSFI SVAAQLAMER FNRLLNRPKG ISKDEFDKLP   150
VLQVSDLPKA EGPLCSICYD EYEDEVDSTK AKRKRDSENE EESEGTKKRK   200
DNEGAPLRTT ADNDSNPSIT NATVVEPPSI PLTEQQRTLN DEETNPSYKH   250
SPIKLPCGHI FGRECIYKWS RLENSCPLCR QKISESVGVQ RAAQQDTDEV   300
AANEAAFERI RRVLYDPTAV NSTNENSSAP SENTSNTTVP TIGNASSGEQ   350
MLSRTGFFLV PQNGQPLHNP VRLPPNDSDR NGVNGPSSTT QNPPSNSGGS   400
NNNQSPRWVP IPLTLFQFHS PNPNPSASDS SASPSAANGP NSNNTSSDAT   450
DPHHNRLRAV LDHIFNVAQR GTSDTSATTA PGAQTVHNQG RNDSSSSDTT   500
QGSSFLENIS RLTGHFTNGS RDNNNDNNHS NDQQRGGSTG ENNRNNLFSS   550
GVASYRNQNG DVTTVELRNN NSAAFPPTDE NPSQGQGSSS SDTTIHNDVP   600
NDNNEQRSSQ                                                610