SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameMOT2
Systematic nameYER068W
AliasNOT4, SIG1
DescriptionComponent of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates subunits of the nascent polypeptide-associated complex (NAC).

Ubiquitination Features
Num. of substrates Total 1 wild-type known substrates.
Wild-type substrate
KeywordDescription
EGD2Nascent polypeptide-associated complex subunit alpha

Cross References
Swiss-Prot accessionP34909
SGD YER068W
Gene Ontology (GO)
Cellular componentGO:0030015CCR4-NOT core complexIPI:SGD.
Cellular componentGO:0005737cytoplasmIDA:SGD.
Molecular functionGO:0016564transcriptional repressor activityTAS:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0000747conjugation with cellular fusionIMP:SGD.
Biological processGO:0000289poly(A) tail shorteningIDA:SGD.
Biological processGO:0016567protein ubiquitinationIDA:SGD.
Biological processGO:0006357regulation of transcription from RNA polyme...IPI:SGD.
Biological processGO:0006368RNA elongation from RNA polymerase II promoterIMP:SGD.
Biological processGO:0000723telomere maintenanceIMP:SGD.
EC number

Additional Features
Post Translational Modifications (PTM)
Residue indexType
298Phosphoserine.
310Phosphothreonine.
312Phosphoserine.

Sequence Information
Sequence length587
Molecular weight65354

	---------+----------+----------+----------+----------+
MMNPHVQENL QAIHNALSNF DTSFLSEDEE DYCPLCIEPM DITDKNFFPC   50
PCGYQICQFC YNNIRQNPEL NGRCPACRRK YDDENVRYVT LSPEELKMER   100
AKLARKEKER KHREKERKEN EYTNRKHLSG TRVIQKNLVY VVGINPPVPY   150
EEVAPTLKSE KYFGQYGKIN KIVVNRKTPH SNNTTSEHYH HHSPGYGVYI   200
TFGSKDDAAR CIAQVDGTYM DGRLIKAAYG TTKYCSSYLR GLPCPNPNCM   250
FLHEPGEEAD SFNKRELHNK QQAQQQSGGT AFTRSGIHNN ISTSTAGSNT   300
NLLSENFTGT PSPAAMRAQL HHDSHTNAGT PVLTPAPVPA GSNPWGVTQS   350
ATPVTSINLS KNSSSINLPT LNDSLGHHTT PTTENTITST TTTTNTNATS   400
HSHGSKKKQS LAAEEYKDPY DALGNAVDFL DARLHSLSNY QKRPISIKSN   450
IIDEETYKKY PSLFSWDKIE ASKKSDNTLA NKLVEILAIK PIDYTASVVQ   500
FLQSVNVGVN DNITITDNTK TPTQPIRLQT VSQQIQPPLN VSTPPPGIFG   550
PQHKVPIQQQ QMGDTSSRNS SDLLNQLING RKIIAGN                 587