SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameHRD1
Systematic nameYOL013C
AliasDER3
DescriptionUbiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger.

Ubiquitination Features
Num. of substrates Total 1 wild-typeand 3 mutant known substrates.
Wild-type substrate
KeywordDescription
HMG23-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Mutant substrate
KeywordWild type description
mPDR5Pleiotropic ABC efflux transporter of multiple drugs
mPRC1Carboxypeptidase Y [Precursor]
mSEC61Protein transport protein SEC61

Cross References
Swiss-Prot accessionQ08109
SGD YOL013C
Gene Ontology (GO)
Cellular componentGO:0005789endoplasmic reticulum membraneIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0030433ER-associated protein catabolic processIMP:SGD.
EC number 6.3.2.-

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length551
Molecular weight63535

	---------+----------+----------+----------+----------+
MVPENRRKQL AIFVVVTYLL TFYCVYSATK TSVSFLQVTL KLNEGFNLMV   50
LSIFILLNST LLWQLLTKLL FGELRLIEHE HIFERLPFTI INTLFMSSLF   100
HERYFFTVAF FGLLLLYLKV FHWILKDRLE ALLQSINDST TMKTLIFSRF   150
SFNLVLLAVV DYQIITRCIS SIYTNQKSDI ESTSLYLIQV MEFTMLLIDL   200
LNLFLQTCLN FWEFYRSQQS LSNENNHIVH GDPTDENTVE SDQSQPVLND   250
DDDDDDDDRQ FTGLEGKFMY EKAIDVFTRF LKTALHLSML IPFRMPMMLL   300
KDVVWDILAL YQSGTSLWKI WRNNKQLDDT LVTVTVEQLQ NSANDDNICI   350
ICMDELIHSP NQQTWKNKNK KPKRLPCGHI LHLSCLKNWM ERSQTCPICR   400
LPVFDEKGNV VQTTFTSNSD ITTQTTVTDS TGIATDQQGF ANEVDLLPTR   450
TTSPDIRIVP TQNIDTLAMR TRSTSTPSPT WYTFPLHKTG DNSVGSSRSA   500
YEFLITNSDE KENGIPVKLT IENHEVNSLH GDGGEQIAKK IVIPDKFIQH   550
I                                                        551