SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameCDH1
Systematic nameYGL003C
AliasHCT1
DescriptionCell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1.

Ubiquitination Features
Num. of substrates Total 9 wild-type known substrates.
Wild-type substrate
KeywordDescription
ASE1Anaphase spindle elongation protein
CDC20APC/C activator protein CDC20
CDC5Cell cycle serine/threonine-protein kinase CDC5/MSD2
CIN8Kinesin-like protein CIN8
CLB2G2/mitotic-specific cyclin-2
CLB3G2/mitotic-specific cyclin-3
FIN1Filament protein FIN1
HSL1Probable serine/threonine-protein kinase HSL1
MPS1Serine/threonine-protein kinase MPS1

Cross References
Swiss-Prot accessionP53197
SGD YGL003C
Gene Ontology (GO)
Cellular componentGO:0005680anaphase-promoting complexTAS:SGD.
Cellular componentGO:0005737cytoplasmIDA:SGD.
Molecular functionGO:0008047enzyme activator activityTAS:SGD.
Biological processGO:0007092anaphase-promoting complex activation durin...IMP:SGD.
Biological processGO:0000070mitotic sister chromatid segregationTAS:SGD.
Biological processGO:0000022mitotic spindle elongationTAS:SGD.
Biological processGO:0016567protein ubiquitinationIPI:SGD.
Biological processGO:0008361regulation of cell sizeIMP:SGD.
Biological processGO:0000723telomere maintenanceIMP:SGD.
EC number

Additional Features
Post Translational Modifications (PTM)
Residue indexType
157Phosphothreonine.

Sequence Information
Sequence length566
Molecular weight62821

	---------+----------+----------+----------+----------+
MSTNLNPFMN NTPSSSPLKG SESKRVSKRP ISSSSSASLL SSPSRRSRPS   50
TVYGDRYIPS RTDIDFNSIV SISSMASVPA LNPSSTEDQV EYQKERQAHE   100
TYNTLLKNEL FGEMLSKDTV GSESSIDRIK NTRPSTRGNV HAENTTRHGY   150
ELERVSTPPP EAAGLEEFSP HSTPVTPRRL FTSQQDEITR PSSNSVRGAS   200
LLTYQQRKGR RLSAASLLQS QFFDSMSPVR PDSKQLLLSP GKQFRQIAKV   250
PYRVLDAPSL ADDFYYSLID WSSTDVLAVA LGKSIFLTDN NTGDVVHLCD   300
TENEYTSLSW IGAGSHLAVG QANGLVEIYD VMKRKCIRTL SGHIDRVACL   350
SWNNHVLTSG SRDHRILHRD VRMPDPFFET IESHTQEVCG LKWNVADNKL   400
ASGGNDNVVH VYEGTSKSPI LTFDEHKAAV KAMAWSPHKR GVLATGGGTA   450
DRRLKIWNVN TSIKMSDIDS GSQICNMVWS KNTNELVTSH GYSKYNLTLW   500
DCNSMDPIAI LKGHSFRVLH LTLSNDGTTV VSGAGDETLR YWKLFDKPKA   550
KVQPNSLIFD AFNQIR                                        566