SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameCDC4
Systematic nameYFL009W
DescriptionF-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p.

Ubiquitination Features
Num. of substrates Total 10 wild-type known substrates.
Wild-type substrate
KeywordDescription
CDC4Cell division control protein 4
CDC6Cell division control protein 6
CLB6S-phase entry cyclin-6
CTF13Centromere DNA-binding protein complex CBF3 subunit C
FAR1Cyclin-dependent kinase inhibitor FAR1
GCN4General control protein GCN4
HAC1Transcriptional activator HAC1
HSL1Probable serine/threonine-protein kinase HSL1
SIC1Protein SIC1
TEC1Ty transcription activator TEC1

Cross References
Swiss-Prot accessionP07834
SGD YFL009W
Gene Ontology (GO)
Cellular componentGO:0016363nuclear matrixIDA:SGD.
Cellular componentGO:0043224nuclear SCF ubiquitin ligase complexIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Biological processGO:0000082G1/S transition of mitotic cell cycleIMP:SGD.
Biological processGO:0000086G2/M transition of mitotic cell cycleIGI:SGD.
Biological processGO:0007126meiosisIMP:SGD.
Biological processGO:0042787protein ubiquitination during ubiquitin-dep...IDA:SGD.
Biological processGO:0031146SCF-dependent proteasomal ubiquitin-depende...IDA:SGD.
EC number

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length779
Molecular weight86090

	---------+----------+----------+----------+----------+
MGSFPLAEFP LRDIPVPYSY RVSGGIASSG SVTALVTAAG THRNSSTAKT   50
VETEDGEEDI DEYQRKRAAG SGESTPERSD FKRVKHDNHK TLHPVNLQNT   100
GAASVDNDGL HNLTDISNDA EKLLMSVDDG SAAPSTLSVN MGVASHNVAA   150
PTTVNAATIT GSDVSNNVNS ATINNPMEEG ALPLSPTASS PGTTTPLAKT   200
TKTINNNNNI ADLIESKDSI ISPEYLSDEI FSAINNNLPH AYFKNLLFRL   250
VANMDRSELS DLGTLIKDNL KRDLITSLPF EISLKIFNYL QFEDIINSLG   300
VSQNWNKIIR KSTSLWKKLL ISENFVSPKG FNSLNLKLSQ KYPKLSQQDR   350
LRLSFLENIF ILKNWYNPKF VPQRTTLRGH MTSVITCLQF EDNYVITGAD   400
DKMIRVYDSI NKKFLLQLSG HDGGVWALKY AHGGILVSGS TDRTVRVWDI   450
KKGCCTHVFK GHNSTVRCLD IVEYKNIKYI VTGSRDNTLH VWKLPKESSV   500
PDHGEEHDYP LVFHTPEENP YFVGVLRGHM ASVRTVSGHG NIVVSGSYDN   550
TLIVWDVAQM KCLYILSGHT DRIYSTIYDH ERKRCISASM DTTIRIWDLE   600
NIWNNGECSY ATNSASPCAK ILGAMYTLQG HTALVGLLRL SDKFLVSAAA   650
DGSIRGWDAN DYSRKFSYHH TNLSAITTFY VSDNILVSGS ENQFNIYNLR   700
SGKLVHANIL KDADQIWSVN FKGKTLVAAV EKDGQSFLEI LDFSKASKIN   750
YVSNPVNSSS SSLESISTSL GLTRTTIIP                          779