SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameCDC20
Systematic nameYGL116W
AliasPAC5
DescriptionCell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate.

Ubiquitination Features
Num. of substrates Total 6 wild-type known substrates.
Wild-type substrate
KeywordDescription
CLB5S-phase entry cyclin-5
HSL1Probable serine/threonine-protein kinase HSL1
KIP1Kinesin-like protein KIP1
MPS1Serine/threonine-protein kinase MPS1
PDS1Securin
SPO13Meiosis-specific protein SPO13

Cross References
Swiss-Prot accessionP26309
SGD YGL116W
Gene Ontology (GO)
Cellular componentGO:0005680anaphase-promoting complexTAS:SGD.
Molecular functionGO:0008047enzyme activator activityTAS:SGD.
Biological processGO:0007092anaphase-promoting complex activation durin...IMP:SGD.
Biological processGO:0008054cyclin catabolic processTAS:SGD.
Biological processGO:0000070mitotic sister chromatid segregationTAS:SGD.
Biological processGO:0000022mitotic spindle elongationTAS:SGD.
EC number

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length610
Molecular weight67360

	---------+----------+----------+----------+----------+
MPESSRDKGN AAISGNRSVL SIASPTKLNI LSSDWSRNQG KVSKNSLKRS   50
SSLNIRNSKR PSLQASANSI YSRPKITIGA PPLIRRDSSF FKDEFDAKKD   100
KATFSAYSSR SYPTIGSESV VSQTSLSQPT TSREVDEQFT VAADRYIPIL   150
QGASQNKVDP ETLHEALPPP NASPISHLRA QTKIVFKQNV AEACGLDMNK   200
RILQYMPEPP KCSSLRQKSY IMKKRTHYSY QQEQKIPDLI KLRKINTNPE   250
RILDAPGFQD DFYLNLLSWS KKNVLAIALD TALYLWNATT GDVSLLTDFE   300
NTTICSVTWS DDDCHISIGK EDGNTEIWDV ETMSLIRTMR SGLGVRIGSL   350
SWLDTLIATG SRSGEIQIND VRIKQHIVST WAEHTGEVCG LSYKSDGLQL   400
ASGGNDNTVM IWDTRTSLPQ FSKKTHTAAV KALSWCPYSP NILASGGGQT   450
DKHIHFWNSI TGARVGSINT GSQVSSLHWG QSHTSTNGGM MNKEIVATGG   500
NPENAISVYN YETKFKVAEV VHAHEARICC SQLSPDGTTL ATVGGDENLK   550
FYKIFDPRCT GRSREDGLMD GMLGLIGKEG CRTNDKENRS KNSSEIHTRR   600
PSSTSQYLIR                                                610