SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameBRE1
Systematic nameYDL074C
DescriptionE3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain.

Ubiquitination Features
Num. of substrates Total 1 wild-type known substrates.
Wild-type substrate
KeywordDescription
HTB2Histone H2B.2

Cross References
Swiss-Prot accessionQ07457
SGD YDL074C
Gene Ontology (GO)
Cellular componentGO:0005634nucleusIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0004842ubiquitin-protein ligase activityIMP:SGD.
Biological processGO:0006348chromatin silencing at telomereIMP:SGD.
Biological processGO:0016571histone methylationIMP:SGD.
Biological processGO:0016574histone ubiquitinationIMP:SGD.
Biological processGO:0006513protein monoubiquitinationIMP:SGD.
Biological processGO:0042493response to drugIMP:SGD.
Biological processGO:0000723telomere maintenanceIMP:SGD.
EC number 6.3.2.-

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length700
Molecular weight80692

	---------+----------+----------+----------+----------+
MTAEPATKKI KLELSDPSEP LTQSDVIAFQ KEALFRCINR RRVDFEALRK   50
QYELSRRECI DVSRKLANIM ALIVTLARFI ETFCTDANEK QLCREIAQGD   100
ETLIVQRSDS FMKLLTKYGK PNTTDSNTNS NASDHIQELT TELKNLRKSK   150
EELFYENSQL TEEISALKEY YTNIIRKYDR DESFTIKRVF KEDKTDAVKE   200
LREDEKESNE NNIKSGNKDS SAINGDNTSK KSEKGDELVQ AEDERKEDAE   250
NEKLELDLKF SDLRAEINSL SSTIKDLENI RRENEEELIK TRSEVSNLKK   300
QQIAAADQDP DFKSYDHESL LAKIQHLTEQ NAELSEINSS FLSKFQVLAK   350
EKEIYTKKVR EEFQKSLDSL VEMNSSLEKD VVRIRTARDD LLSKIAILEA   400
EKSKTEVLSD LQHAIDILKE QWTKIDQRSN DTKSSSTQDA LIKEIQDLEK   450
GFRELSDLTH KKYSEIINHE SVISKLTVEK TKADQKYFAA MRSKDSILIE   500
IKTLSKSLSK SNELILQLKD SDRLLQQKIG NLHKQLDLSQ NNERRLIDSS   550
KTETLKIIDL NNTSTKLKRS LEKLQEESNK SIADMTHLET KLNDTEIELK   600
HFKQKASHLE SKCEKLHDTL FRGNNKNKGS SDEALVEELA NFRTLVYCSL   650
CSKNWKNMAI KTCGHVFCEN CCKERLAARM RKCPTCNKAF SSNDLLTVHL   700