SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameUBC8
Systematic nameYEL012W
AliasGID3
DescriptionUbiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro.

Ubiquitination Features
Num. of substrates Total 1 wild-type known substrates.
Wild-type substrate
KeywordDescription
FBP1Fructose-1,6-bisphosphatase

Cross References
Swiss-Prot accessionP28263
SGD YEL012W
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Molecular functionGO:0042802identical protein bindingIPI:IntAct.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0045721negative regulation of gluconeogenesisIMP:SGD.
Biological processGO:0006513protein monoubiquitinationTAS:SGD.
Biological processGO:0000209protein polyubiquitinationTAS:SGD.
Biological processGO:0042787protein ubiquitination during ubiquitin-dep...IMP:SGD.
EC number 6.3.2.19

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length218
Molecular weight24633

	---------+----------+----------+----------+----------+
MSSSKRRIET DVMKLLMSDH QVDLINDSMQ EFHVKFLGPK DTPYENGVWR   50
LHVELPDNYP YKSPSIGFVN KIFHPNIDIA SGSICLDVIN STWSPLYDLI   100
NIVEWMIPGL LKEPNGSDPL NNEAATLQLR DKKLYEEKIK EYIDKYATKE   150
KYQQMFGGDN DSDDSDSGGD LQEEDSDSDE DMDGTGVSSG DDSVDELSED   200
LSDIDVSDDD DYDEVANQ                                      218