SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameUBC7
Systematic nameYMR022W
AliasQRI8
DescriptionUbiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly.

Ubiquitination Features
Num. of substrates Total 3 wild-typeand 7 mutant known substrates.
Wild-type substrate
KeywordDescription
HMG23-hydroxy-3-methylglutaryl-coenzyme A reductase 2
HMLALPHA2Mating-type protein ALPHA2
UBC6Ubiquitin-conjugating enzyme E2 6
Mutant substrate
KeywordWild type description
mCBF2Centromere DNA-binding protein complex CBF3 subunit A
mMPS2Uncharacterized protein YGL075C
mPDR5Pleiotropic ABC efflux transporter of multiple drugs
mPMA1Plasma membrane ATPase 1
mPRC1Carboxypeptidase Y [Precursor]
mSEC61Protein transport protein SEC61
mSTE6Mating factor A secretion protein STE6

Cross References
Swiss-Prot accessionQ02159
SGD YMR022W
Gene Ontology (GO)
Cellular componentGO:0005783endoplasmic reticulumTAS:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0006333chromatin assembly or disassemblyIMP:SGD.
Biological processGO:0030433ER-associated protein catabolic processIDA:SGD.
EC number 6.3.2.19

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length165
Molecular weight18520

	---------+----------+----------+----------+----------+
MSKTAQKRLL KELQQLIKDS PPGIVAGPKS ENNIFIWDCL IQGPPDTPYA   50
DGVFNAKLEF PKDYPLSPPK LTFTPSILHP NIYPNGEVCI SILHSPGDDP   100
NMYELAEERW SPVQSVEKIL LSVMSMLSEP NIESGANIDA CILWRDNRPE   150
FERQVKLSIL KSLGF                                         165