SCUD (Saccharomyces Cerevisiae Ubiquitination Database)

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Enzyme Information

General Information
Standard nameUBC4
Systematic nameYBR082C
DescriptionUbiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response.

Ubiquitination Features
Num. of substrates Total 16 wild-typeand 1 mutant known substrates.
Wild-type substrate
CPS1Carboxypeptidase S
CUP9Homeobox protein CUP9
EGD2Nascent polypeptide-associated complex subunit alpha
GAL2Galactose transporter
HMLALPHA2Mating-type protein ALPHA2
HPR1THO complex subunit HPR1
HRT3F-box protein HRT3
MAL61Maltose permease MAL61
ROG1Putative lipase ROG1
SIC1Protein SIC1
STE2Pheromone alpha factor receptor
STE3Pheromone a factor receptor
YLR224WF-box protein YLR224W
YNL311CF-box protein YNL311C
ZRT1Zinc-regulated transporter 1
Mutant substrate
KeywordWild type description
mPRC1Carboxypeptidase Y [Precursor]

Cross References
Swiss-Prot accessionP15731
Gene Ontology (GO)
Cellular componentGO:0000502proteasome complex (sensu Eukaryota)IPI:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0006513protein monoubiquitinationIDA:SGD.
Biological processGO:0000209protein polyubiquitinationIDA:SGD.
Biological processGO:0006950response to stressIDA:SGD.
Biological processGO:0030437sporulation (sensu Fungi)TAS:SGD.
Biological processGO:0043162ubiquitin-dependent protein catabolic proce...IMP:SGD.
EC number

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length148
Molecular weight16456