SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameUBC1
Systematic nameYDR177W
DescriptionUbiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response.

Ubiquitination Features
Num. of substrates Total 3 wild-typeand 2 mutant known substrates.
Wild-type substrate
KeywordDescription
GAL2Galactose transporter
MAL61Maltose permease MAL61
STE2Pheromone alpha factor receptor
Mutant substrate
KeywordWild type description
mPRC1Carboxypeptidase Y [Precursor]
mSIR4Regulatory protein SIR4

Cross References
Swiss-Prot accessionP21734
SGD YDR177W
Gene Ontology (GO)
Cellular componentGO:0000502proteasome complex (sensu Eukaryota)IPI:SGD.
Molecular functionGO:0042802identical protein bindingIPI:IntAct.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0006897endocytosisTAS:SGD.
Biological processGO:0030433ER-associated protein catabolic processIGI:SGD.
Biological processGO:0006513protein monoubiquitinationTAS:SGD.
Biological processGO:0000209protein polyubiquitinationTAS:SGD.
Biological processGO:0042787protein ubiquitination during ubiquitin-dep...IMP:SGD.
Biological processGO:0009847spore germinationTAS:SGD.
Biological processGO:0016050vesicle organization and biogenesisIMP:SGD.
EC number 6.3.2.19

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length215
Molecular weight24178

	---------+----------+----------+----------+----------+
MSRAKRIMKE IQAVKDDPAA HITLEFVSES DIHHLKGTFL GPPGTPYEGG   50
KFVVDIEVPM EYPFKPPKMQ FDTKVYHPNI SSVTGAICLD ILKNAWSPVI   100
TLKSALISLQ ALLQSPEPND PQDAEVAQHY LRDRESFNKT AALWTRLYAS   150
ETSNGQKGNV EESDLYGIDH DLIDEFESQG FEKDKIVEVL RRLGVKSLDP   200
NDNNTANRII EELLK                                         215