SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameRAD6
Systematic nameYGL058W
AliasUBC2
DescriptionUbiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p).

Ubiquitination Features
Num. of substrates Total 6 wild-type known substrates.
Wild-type substrate
KeywordDescription
CUP9Homeobox protein CUP9
GCN4General control protein GCN4
HOHomothallic switching endonuclease
HTB2Histone H2B.2
POL30Proliferating cell nuclear antigen
RPN4Protein RPN4

Cross References
Swiss-Prot accessionP06104
SGD YGL058W
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Cellular componentGO:0005634nucleusIDA:SGD.
Cellular componentGO:0000502proteasome complex (sensu Eukaryota)IPI:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0016574histone ubiquitinationIDA:SGD.
Biological processGO:0006301postreplication repairIMP:SGD.
Biological processGO:0006513protein monoubiquitinationIMP:SGD.
Biological processGO:0000723telomere maintenanceIMP:SGD.
Biological processGO:0006511ubiquitin-dependent protein catabolic processIMP:SGD.
EC number 6.3.2.19

Additional Features
Post Translational Modifications (PTM)
Residue indexType
120Phosphoserine, by SGV1.

Sequence Information
Sequence length172
Molecular weight19706

	---------+----------+----------+----------+----------+
MSTPARRRLM RDFKRMKEDA PPGVSASPLP DNVMVWNAMI IGPADTPYED   50
GTFRLLLEFD EEYPNKPPHV KFLSEMFHPN VYANGEICLD ILQNRWTPTY   100
DVASILTSIQ SLFNDPNPAS PANVEAATLF KDHKSQYVKR VKETVEKSWE   150
DDMDDMDDDD DDDDDDDDDE AD                                 172