SCUD (Saccharomyces Cerevisiae Ubiquitination Database)

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Enzyme Information

General Information
Standard nameCDC34
Systematic nameYDR054C
AliasDNA6, UBC3
DescriptionUbiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation.

Ubiquitination Features
Num. of substrates Total 25 wild-type known substrates.
Wild-type substrate
AAH1Adenosine deaminase
CDC4Cell division control protein 4
CDC6Cell division control protein 6
CLB6S-phase entry cyclin-6
CLN1G1/S-specific cyclin CLN1
CLN2G1/S-specific cyclin CLN2
CTF13Centromere DNA-binding protein complex CBF3 subunit C
CYK2Cytokinesis 2 protein
FAR1Cyclin-dependent kinase inhibitor FAR1
GCN4General control protein GCN4
GIC2GTPase-interacting component 2
GRR1SCF E3 ubiquitin ligase complex F-box protein GRR1
HAC1Transcriptional activator HAC1
HOHomothallic switching endonuclease
IME2Meiosis induction protein kinase IME2/SME1
MET4Transcriptional activator of sulfur metabolism MET4
SIC1Protein SIC1
STD1Protein STD1
STE7Serine/threonine-protein kinase STE7
SWE1Mitosis inhibitor protein kinase SWE1
TEC1Ty transcription activator TEC1
UFO1Ubiquitin ligase complex F-box protein UFO1
YDR306CF-box protein YDR306C
YNL311CF-box protein YNL311C

Cross References
Swiss-Prot accessionP14682
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Cellular componentGO:0005634nucleusIDA:SGD.
Cellular componentGO:0019005SCF ubiquitin ligase complexIDA:SGD.
Molecular functionGO:0042803protein homodimerization activityIDA:SGD.
Molecular functionGO:0004842ubiquitin-protein ligase activityIDA:SGD.
Biological processGO:0000082G1/S transition of mitotic cell cycleTAS:SGD.
Biological processGO:0000086G2/M transition of mitotic cell cycleIGI:SGD.
Biological processGO:0051865protein autoubiquitinationIDA:SGD.
Biological processGO:0000209protein polyubiquitinationIDA:SGD.
Biological processGO:0042787protein ubiquitination during ubiquitin-dep...IDA:SGD.
Biological processGO:0031146SCF-dependent proteasomal ubiquitin-depende...IDA:SGD.
EC number

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length295
Molecular weight34065