SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameUBP6
Systematic nameYFR010W
DescriptionUbiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds.

Ubiquitination Features
Num. of substrates Total 1 wild-type known substrates.
Wild-type substrate
KeywordDescription
TAT2Tryptophan permease

Cross References
Swiss-Prot accessionP43593
SGD YFR010W
Gene Ontology (GO)
Cellular componentGO:0005838proteasome regulatory particle (sensu Eukar...IPI:SGD.
Molecular functionGO:0004843ubiquitin-specific protease activityTAS:SGD.
Biological processGO:0016579protein deubiquitinationTAS:SGD.
EC number 3.1.2.15

Additional Features
Post Translational Modifications (PTM)
Residue indexType
383Phosphoserine.
389Phosphothreonine.
470Phosphoserine.

Sequence Information
Sequence length499
Molecular weight57111

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MSGETFEFNI RHSGKVYPIT LSTDATSADL KSKAEELTQV PSARQKYMVK   50
GGLSGEESIK IYPLIKPGST VMLLGTPDAN LISKPAKKNN FIEDLAPEQQ   100
VQQFAQLPVG FKNMGNTCYL NATLQALYRV NDLRDMILNY NPSQGVSNSG   150
AQDEEIHKQI VIEMKRCFEN LQNKSFKSVL PIVLLNTLRK CYPQFAERDS   200
QGGFYKQQDA EELFTQLFHS MSIVFGDKFS EDFRIQFKTT IKDTANDNDI   250
TVKENESDSK LQCHISGTTN FMRNGLLEGL NEKIEKRSDL TGANSIYSVE   300
KKISRLPKFL TVQYVRFFWK RSTNKKSKIL RKVVFPFQLD VADMLTPEYA   350
AEKVKVRDEL RKVEKEKNEK EREIKRRKFD PSSSENVMTP REQYETQVAL   400
NESEKDQWLE EYKKHFPPNL EKGENPSCVY NLIGVITHQG ANSESGHYQA   450
FIRDELDENK WYKFNDDKVS VVEKEKIESL AGGGESDSAL ILMYKGFGL    499