SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameUBP2
Systematic nameYOR124C
DescriptionUbiquitin-specific protease that removes ubiquitin from ubiquitinated proteins, cleaves at the C terminus of ubiquitin fusions; capable of cleaving polyubiquitin and possesses isopeptidase activity.

Ubiquitination Features
Num. of substrates Total 2 wild-type known substrates.
Wild-type substrate
KeywordDescription
CSR2Transcription factor CSR2
ECM21Protein ECM21

Cross References
Swiss-Prot accessionQ01476
SGD YOR124C
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIC:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0004843ubiquitin-specific protease activityIDA:SGD.
Biological processGO:0016579protein deubiquitinationIDA:SGD.
EC number 3.1.2.15

Additional Features
Post Translational Modifications (PTM)
Residue indexType
875Phosphothreonine.
907Phosphoserine.

Sequence Information
Sequence length1272
Molecular weight146355

	---------+----------+----------+----------+----------+
MPNEDNELQK AIENHHNQLL NQDKENADRN GSVIEDLPLY GTSINQQSTP   50
GDVDDGKHLL YPDIATNLPL KTSDRLLDDI LCDTIFLNST DPKVMQKGLQ   100
SRGILKESML SYSTFRSSIR PNCLGSLTDQ VVFQTKSEYD SISCPKYNKI   150
HVFQAVIFNP SLAEQQISTF DDIVKIPIYH LKVSVKVRQE LERLKKHVGV   200
TQFHSLDHLH EYDRVDLSTF DSSDPNLLDY GIYVSDDTNK LILIEIFKPE   250
FNSPEEHESF TADAIKKRYN AMCVKNESLD KSETPSQVDC FYTLFKIFKG   300
PLTRKSKAEP TKTIDSGNLA LNTHLNPEWL TSKYGFQASS EIDEETNEIF   350
TEYVPPDMVD YVNDLETRKI RESFVRKCLQ LIFWGQLSTS LLAPNSPLKN   400
TKSVKGMSSL QTSFSTLPWF HLLGESRARI LLNSNEQTHS PLDAEPHFIN   450
LSVSHYYTDR DIIRNYESLS SLDPENIGLY FDALTYIANR KGAYQLIAYC   500
GKQDIIGQEA LENALLMFKI NPKECNISEL NEATLLSIYK YETSNKSQVT   550
SNHLTNLKNA LRLLAKYTKS DKLKFYVDHE PYRALSQAYD TLSIDESVDE   600
DIIKTAYSVK INDSPGLKLD CDRALYTIAI SKRSLDLFNF LTEECPQFSN   650
YYGPEKLDYQ EALKLLQVNE NASDETILKI FKQKWFDENV YEPDQFLILR   700
AALTKISIER NSTLITNFLL TGTIDPNSLP PENWPTGINN IGNTCYLNSL   750
LQYYFSIAPL RRYVLEYQKT VENFNDHLSN SGHIRRIGGR EISRGEVERS   800
IQFIYQLRNL FYAMVHTRER CVTPSKELAY LAFAPSNVEV EFEVEGNKVV   850
DQTGVLSDSK KETTDDAFTT KIKDTSLIDL EMEDGLNGDV GTDANRKKNE   900
SNDAEVSENE DTTGLTSPTR VAKISSDQLE NALEMGRQQD VTECIGNVLF   950
QIESGSEPIR YDEDNEQYDL VKQLFYGTTK QSIVPLSATN KVRTKVERFL   1000
SLLINIGDHP KDIYDAFDSY FKDEYLTMEE YGDVIRTVAV TTFPTILQVQ   1050
IQRVYYDRER LMPFKSIEPL PFKEVIYMDR YADTENPLLL AKKKETEEMK   1100
QKLKVMKNRQ RELLSRDDSG LTRKDAFLES IKLLESDTIK KTPLKIEAAN   1150
DVIKTLRNNV QNIDNELMKL YNDINSLEEK ISHQFDDFKE YGYSLFSVFI   1200
HRGEASYGHY WIYIKDRNRN GIWRKYNDET ISEVQEEEVF NFNEGNTATP   1250
YFLVYVKQGQ EGDIEPLKRI LK                                 1272