SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Enzyme Information

General Information
Standard nameOTU1
Systematic nameYFL044C
DescriptionDeubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family.

Ubiquitination Features
Num. of substrates Total 1 wild-type known substrates.
Wild-type substrate
KeywordDescription
SPT23Protein SPT23

Cross References
Swiss-Prot accessionP43558
SGD YFL044C
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Cellular componentGO:0005634nucleusIDA:SGD.
Molecular functionGO:0004843ubiquitin-specific protease activityIDA:SGD.
Biological processGO:0016579protein deubiquitinationIDA:SGD.
Biological processGO:0045449regulation of transcriptionIMP:SGD.
EC number 3.1.2.-

Additional Features
Post Translational Modifications (PTM) PTM sites are not determined.

Sequence Information
Sequence length301
Molecular weight33510

	---------+----------+----------+----------+----------+
MKLKVTGAGI NQVVTLKQDA TLNDLIEHIN VDVKTMRFGY PPQRINLQGE   50
DASLGQTQLD ELGINSGEKI TIESSDSNES FSLPPPQPKP KRVLKSTEMS   100
IGGSGENVLS VHPVLDDNSC LFHAIAYGIF KQDSVRDLRE MVSKEVLNNP   150
VKFNDAILDK PNKDYAQWIL KMESWGGAIE IGIISDALAV AIYVVDIDAV   200
KIEKFNEDKF DNYILILFNG IHYDSLTMNE FKTVFNKNQP ESDDVLTAAL   250
QLASNLKQTG YSFNTHKAQI KCNTCQMTFV GEREVARHAE STGHVDFGQN   300
R                                                        301