SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameTSR1
Systematic nameYDL060W
DescriptionRibosome biogenesis protein TSR1

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1 MULTI    RPN10 Proteasomal Degradation
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (ubiquitin-chain by UBA domain-containing protein, 6xHis-ubiquitin (two-step)), LC/MS
Reference"Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets."
Mayor T, Lipford JR, Graumann J, Smith GT, Deshaies RJ.
Mol Cell Proteomics. 4(6):741-51 (2005) [15699485]

Cross References
Swiss-Prot accessionQ07381
SGD YDL060W
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Cellular componentGO:0005730nucleolusIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0043021ribonucleoprotein bindingIDA:SGD.
Biological processGO:0006364rRNA processingIMP:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length788
Molecular weight90748

	---------+----------+----------+----------+----------+
MAGHSHRSSL KNGHKSYKSK HASKGALKRL YKGKVEKEPV GTGKPDKQVS   50
KLQRKNKAKQ LRAQRILDSI ENRKLFEGKN GAAKIITIVP LVNDLDPLDI   100
LYKLLKCADD EGIMVQEVDS KRIFNVHIKK FKSNLKIIIP DMTNFLNILD   150
CAKVADFVVF GLSGVQEVDE EFGEQIIRAL ELQGIASYIG VISNLSAVHE   200
KEKFQLDVKQ SLESYFKHFF PSEERVYNLE KNSDALNVLR TLCQRLPRSI   250
NWRDNRGYVV ADFVDFVETS PDSGDLVIEG TVRGIGFNAN RLVHIPDFGD   300
FQLNKIEKIS ESSQKRKIIK EKATDSLSLE LDLQTVFESN MNRDTLDEYA   350
PEGTEDWSDY DEDFEYDGLT TARYDDHGFL PGREQTSKKA AVPKGTSDYQ   400
AKWYLDDVID ANEEEEAEQT NGKDETMMEI DDEMMVEQDN EEVAGDEEYD   450
IEDNEGFEEL SPEEEERQLR EFRDMEKEDR EFPDEIELEP SESAIERLKR   500
YRGLKNLYNC DWQVDEKDPS SPAEWKRLLR IGNYKNTKNR IIKETKNEAQ   550
AIAGDRIRMF IRFPKFLLEK IQDPKQLLFA VYGLLLHEHK NAVVNFSLQR   600
WEQYDKPVPS QEPIVVQYGV RRYTIQPLFS QGSNSPNNVH KYERFLHPDT   650
VSVATCIAPV DFTQSPAIFF KPSPTDAKNI ELIGHGTFLN ADHSRILAKR   700
AILTGHPFRF HKTVVTVRYM FFRPEDVEWF KSIPLFTKSG RSGFIKESLG   750
THGYFKATFD GKLSAQDVVA MSLYKRMWPM PSLPWNGM                788