SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameTSC11
Systematic nameYER093C
AliasAVO3
DescriptionTarget of rapamycin complex 2 subunit TSC11

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1         
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (6xHis-Myc-ubiquitin), LC/MS, validation (virtual Western blot)
Reference"Systematic approach for validating the ubiquitinated proteome."
Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
Anal Chem. 80(11):4161-9 (2008) [18433149]

Cross References
Swiss-Prot accessionP40061
SGD YER093C
Gene Ontology (GO)
Cellular componentGO:0031932TORC 2 complexIPI:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Biological processGO:0007047cell wall organization and biogenesisIGI:SGD.
Biological processGO:0030950establishment and/or maintenance of actin c...IMP:SGD.
Biological processGO:0001558regulation of cell growthIPI:SGD.
Biological processGO:0030148sphingolipid biosynthetic processIGI:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)
Residue indexType
86Phosphothreonine.
87Phosphoserine.

Sequence Information
Sequence length1430
Molecular weight164368

	---------+----------+----------+----------+----------+
MSIPHSAKQS SPLSSRRRSV TNTTPLLTPR HSRDNSSTQI SSAKNITSSS   50
PSTITNESSK RNKQNLVLST SFISTKRLEN SAPSPTSPLM ARRTRSTMTK   100
ALLNLKAEIN NQYQELARLR KKKDDIEHLR DSTISDIYSG SYSTNHLQKH   150
SMRIRANTQL REIDNSIKRV EKHIFDLKQQ FDKKRQRSLT TSSSIKADVG   200
SIRNDDGQNN DSEELGDHDS LTDQVTLDDE YLTTPTSGTE RNSQQNLNRN   250
STVNSRNNEN HSTLSIPDLD GSNKVNLTGD TEKDLGDLEN ENQIFTSTTT   300
EAATWLVSDY MQSFQEKNVN PDFIAQKANG LVTLLKEHSE IRKDLVLTSF   350
MSSIQNLLLN GNKLIAASAY RVCRYLINSS IFIDELLELR LDAFIIISLA   400
KDNSFQIERE QALKMVRRFI EYNNGVTQGI MQAIISCVEK PEDSLRHMAL   450
ETLLELCFVA PEMVKECRGM RVIEGFLQDY TSFSLASVIL DTILQLMATH   500
KTRQHFLEDF NVSVLTTVFS DTNTKSNVNV EKMQNASTLI SITLNSYNGF   550
MLFSNNNFKP LKQLVSFFQI PICAQYLIDI FLDVLKIKPL PYKPRGRHSH   600
SFKPIPSQYY KECMSVNQRL ALIVLILENS EFVPHLLELL NEEDRDDHLV   650
AKGRYLLTEY FNLRMNLVDK KYTSVSKPIY KENFTYVNET FQFKKIAYKM   700
NRNRNTIGMS GIDYAQNIKS FSKNIKENTL LREVDDFRFR RMVYDSKVLQ   750
TKDFTRWNWN IINELLEGPL LNKKQLEELV KSTKFIRRLL VFYRPLRLRF   800
SNVNKGAKLS QKYVQVGCQF FKTLTATPEG MKILMDDTKI IPQLASLMFR   850
AMEGNISGNI FNKNKLREKI IFGYFKFIGI LTQSKNGVHI LTRWNFFTVI   900
YKMFQFESKL GLEFLLLTIP ELDLKYSSHC RVIIGKALVV ANEKVRIEAT   950
KHIGDKLKEL LSTKESDLKL KANKVKLQQF KMEMLTRQLY DLSPSVVAVA   1000
DQALYECIVA GNGSEELGTS FRMFLNQMVF IRSPILFELL SRPYGFQLLN   1050
EINFVKEERD SWLSKKNIEY VHIVEEFLKK NESINAKSLT FQQKSRLPLH   1100
FYESLTKTED GILLLSQTGD LVTFMNVIKK YVNGNNMATV ENAKEILDLK   1150
AALWCVGFIG STELGIGLLD NYSLVEDIIE VAYNASVTSV RFTAFYVLGL   1200
ISMTREGCEI LDEMGWNCCV SVQDEPIGIA LPNRLDRFLS YNEHKWSAFG   1250
EYSDEMIVFN KSDGDLIEKC LPIEFDLDKL LKEKDTAENP LNEKIITNKY   1300
DNDITSQTIT VSGENSSLFA NEGLSSPYVT QYRNDDDSIE SKVLHIVSQL   1350
GNHILSNHAV KEITEINNKY GPRLFENEKM FFKVFNMMSK YRFKPHVRKF   1400
LCGLFINNRA LENVIRHDNK RDKRPANFTR                          1430