SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard namePTH2
Systematic nameYBL057C
DescriptionPeptidyl-tRNA hydrolase 2

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1K158        
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (6xHis-Myc-ubiquitin), LC/MS
Reference"A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
Hitchcock AL, Auld K, Gygi SP, Silver PA.
Proc Natl Acad Sci U S A. 100(22):12735-40 (2003) [14557538]

Cross References
Swiss-Prot accessionP34222
SGD YBL057C
Gene Ontology (GO)
Cellular componentGO:0005741mitochondrial outer membraneIDA:SGD.
Molecular functionGO:0004045aminoacyl-tRNA hydrolase activityIDA:SGD.
Biological processGO:0032435negative regulation of proteasomal ubiquiti...IDA:SGD.
Biological processGO:0006412translationIC:SGD.
EC number 3.1.1.29

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length214
Molecular weight23128

	---------+----------+----------+----------+----------+
MITSFLMEKM TVSSNYTIAL WATFTAISFA VGYQLGTSNA SSTKKSSATL   50
LRSKEMKEGK LHNDTDEEES ESEDESDEDE DIESTSLNDI PGEVRMALVI   100
RQDLGMTKGK IAAQCCHAAL SCFRHIATNP ARASYNPIMT QRWLNAGQAK   150
ITLKCPDKFT MDELYAKAIS LGVNAAVIHD AGRTQIAAGS ATVLGLGPAP   200
KAVLDQITGD LKLY                                          214

	* Ubiquitinated lysine is denoted as red color.