SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard namePOM152
Systematic nameYMR129W
DescriptionNucleoporin POM152

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1        Proteasomal Degradation
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (ubiquitin-chain by UBA domain-containing protein, 6xHis-ubiquitin (two-step)), LC/MS, validation (statistical quantitative analysis)
Reference"Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway."
Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ.
Mol Cell Proteomics. 6(11):1885-95 (2007) [17644757]

Cross References
Swiss-Prot accessionP39685
SGD YMR129W
Gene Ontology (GO)
Cellular componentGO:0005739mitochondrionIDA:SGD.
Cellular componentGO:0005643nuclear poreIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0005198structural molecule activityTAS:SGD.
Biological processGO:0006406mRNA export from nucleusTAS:SGD.
Biological processGO:0006609mRNA-binding (hnRNP) protein import into nu...TAS:SGD.
Biological processGO:0006607NLS-bearing substrate import into nucleusTAS:SGD.
Biological processGO:0006999nuclear pore organization and biogenesisTAS:SGD.
Biological processGO:0006611protein export from nucleusTAS:SGD.
Biological processGO:0006610ribosomal protein import into nucleusTAS:SGD.
Biological processGO:0006407rRNA export from nucleusTAS:SGD.
Biological processGO:0006408snRNA export from nucleusTAS:SGD.
Biological processGO:0006608snRNP protein import into nucleusTAS:SGD.
Biological processGO:0006409tRNA export from nucleusTAS:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)
Residue indexType
45Phosphoserine.
60Phosphoserine.

Sequence Information
Sequence length1337
Molecular weight151653

	---------+----------+----------+----------+----------+
MEHRYNVFND TPRGNHWMGS SVSGSPRPSY SSRPNVNTTR RFQYSDDEPA   50
EKIRPLRSRS FKSTESNISD EKSRISERDS KDRYINGDKK VDIYSLPLIS   100
TDVLEISKQR TFAVILFLII QCYKIYDLVI LKSGLPLSGL LFKNYRFNFI   150
SKYFIIDSFF LYVLPSFNIP RLTFKPWVVY LQILAMLLLN IFISSDHEFV   200
LISLIMTTWR KLYTKELSVT GSAINHHRIF DSSAHFKGAL TIKILPENTA   250
MFNPLHESYC LPMDTNLFKI NSIDVPIRIN STEEIEYIEL EYRDLYTNSV   300
ELRSLSKKDF KIIDNPKSFL KKDQSVLKSH SNDFEEGSTI RYLAVTLQDI   350
GFYQIKKIVD SKKLNLKIHQ SHLVVPYCPI ASITGTGSND RCIGDSDNVS   400
FEIQGVPPMK LAYSKIVNGQ TFSYVDSSLQ PEYFESPLQS SKSKQSFTQG   450
ELNDLKWGRN QPVNINLDSS ITQDGKFAYK IDKITDGLGN VVDFTSLPEE   500
LKKRYDLSYN FNVHEVPRAA LEERFDPKSP TKRSIAIVFE EIKNWISDIP   550
YVISLSYTDA QDKSKKIMNV TTDSLTKVLQ ADLPGSYNLE YIESKFCPGE   600
IVGKSNVLVT MPVAPTMEVK SFPILDQCVG QVGLNFELSF TGAPPYYYNT   650
KIYKLENGER KLYDAKRYTS EGTRNRFSYS PPKEGNYEIV FDTVSNKLFT   700
EPIKLEPVKE YTFKTSMRVK PSASLKLHHD LKLCLGDHSS VPVALKGQGP   750
FTLTYDIIET FSSKRKTFEI KEIKTNEYVI KTPVFTTGGD YILSLVSIKD   800
STGCVVGLSQ PDAKIQVRRD IPSAAFNFFE PIKEAKIKHG SVTEIPLKLS   850
GEGPFTVKFK HMDYDGNIVK EFENKFQNSY KPALKVSKEG LYQLVDIRDS   900
SCQGNVIYRN SLYKVSFLEK PKFAIQDNHH ITKVTENLFS KEEVCQGMEG   950
TVDLALFGSP PFILEYDLMA PNGHISTKKI QVATKYASLK LPNQIPGEYI   1000
TTIKAIFDGN YGESDIHFRE HQSELIIKQT VHPIPDVAFA DGGKTLRACA   1050
ANVDQISFLE PINLKFLQGE SPFSITFSVY HESTSRTDQY TIDNIDSENF   1100
SFEKLYEGMK LGNHAITIDS VVDANGCVNS LISGPRNQIL VSITDAPKIH   1150
ILDPSTEYCV GDYVAYQLNG VAPFMIKYEF NGIPLKSKER SSQFVRLASE   1200
PGIISITSLQ DSSSQCIVDF TNPKLKSEFD DLSLNIHPIP SVTVSQGNYV   1250
TEDIREGDQA EVIFSFEGTP PFSLTYVRTE ETDGKHGKRR SQVVETHKVT   1300
DIYSHEYKVI TSLQGTYEAI EITDAYCFAK NDLFFNN                 1337