SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard namePDC6
Systematic nameYGR087C
DescriptionPyruvate decarboxylase isozyme 3

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1        Proteasomal Degradation
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (ubiquitin-chain by UBA domain-containing protein, 6xHis-ubiquitin (two-step)), LC/MS, validation (statistical quantitative analysis)
Reference"Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway."
Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ.
Mol Cell Proteomics. 6(11):1885-95 (2007) [17644757]

Cross References
Swiss-Prot accessionP26263
SGD YGR087C
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Molecular functionGO:0004737pyruvate decarboxylase activityIMP:SGD.
Biological processGO:0006067ethanol metabolic processIMP:SGD.
EC number 4.1.1.1,4.1.1.-

Additional Features
Other Post Translational Modifications (PTM)
Residue indexType
2N-acetylserine (By similarity).

Sequence Information
Sequence length563
Molecular weight61580

	---------+----------+----------+----------+----------+
MSEITLGKYL FERLKQVNVN TIFGLPGDFN LSLLDKIYEV DGLRWAGNAN   50
ELNAAYAADG YARIKGLSVL VTTFGVGELS ALNGIAGSYA EHVGVLHVVG   100
VPSISAQAKQ LLLHHTLGNG DFTVFHRMSA NISETTSMIT DIATAPSEID   150
RLIRTTFITQ RPSYLGLPAN LVDLKVPGSL LEKPIDLSLK PNDPEAEKEV   200
IDTVLELIQN SKNPVILSDA CASRHNVKKE TQKLIDLTQF PAFVTPLGKG   250
SIDEQHPRYG GVYVGTLSKQ DVKQAVESAD LILSVGALLS DFNTGSFSYS   300
YKTKNVVEFH SDYVKVKNAT FLGVQMKFAL QNLLKVIPDV VKGYKSVPVP   350
TKTPANKGVP ASTPLKQEWL WNELSKFLQE GDVIISETGT SAFGINQTIF   400
PKDAYGISQV LWGSIGFTTG ATLGAAFAAE EIDPNKRVIL FIGDGSLQLT   450
VQEISTMIRW GLKPYLFVLN NDGYTIEKLI HGPHAEYNEI QTWDHLALLP   500
AFGAKKYENH KIATTGEWDA LTTDSEFQKN SVIRLIELKL PVFDAPESLI   550
KQAQLTAATN AKQ                                           563