SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


Main Search Enzymes Substrates Ubiquitination types BLAST Feedback HELP

Substrate Information

General Information
Standard nameMPS1
Systematic nameYDL028C
AliasRPK1
DescriptionSerine/threonine-protein kinase MPS1

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1   RINGAPCCDC20   
2   RINGAPCCDH1   
* Blank: not determined, NA: not applicable.

References
[1]EvidenceProtein Stability Assay
MethodWestern blot
Reference"Anaphase inactivation of the spindle checkpoint."
Palframan WJ, Meehl JB, Jaspersen SL, Winey M, Murray AW.
Science. 313(5787):680-4 (2006) [16825537]
[2]EvidenceProtein Stability Assay
MethodWestern blot
Reference"Anaphase inactivation of the spindle checkpoint."
Palframan WJ, Meehl JB, Jaspersen SL, Winey M, Murray AW.
Science. 313(5787):680-4 (2006) [16825537]

Cross References
Swiss-Prot accessionP54199
SGD YDL028C
Gene Ontology (GO)
Cellular componentGO:0000778condensed nuclear chromosome kinetochoreIDA:SGD.
Cellular componentGO:0005816spindle pole bodyIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Molecular functionGO:0004712protein threonine/tyrosine kinase activityIDA:SGD.
Biological processGO:0007094mitotic spindle checkpointTAS:SGD.
Biological processGO:0051225spindle assemblyIMP:SGD.
Biological processGO:0007103spindle pole body duplication in nuclear en...TAS:SGD.
EC number 2.7.12.2

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length764
Molecular weight86828

	---------+----------+----------+----------+----------+
MSTNSFHDYV DLKSRTNTRQ FSDDEEFTTP PKLSNFGSAL LSHTEKTSAS   50
EILSSHNNDK IANRLEEMDR SSSRSHPPPS MGNLTSGHTS TSSHSTLFGR   100
YLRNNHQTSM TTMNTSDIEI NVGNSLDKSF ERIRNLRQNM KEDITAKYAE   150
RRSKRFLISN RTTKLGPAKR AMTLTNIFDE DVPNSPNQPI NARETVELPL   200
EDSHQTNFKE RRENTDYDSI DFGDLNPIQY IKKHNLPTSD LPLISQIYFD   250
KQREENRQAA LRKHSSRELL YKSRSSSSSL SSNNLLANKD NSITSNNGSQ   300
PRRKVSTGSS SSKSSIEIRR ALKENIDTSN NSNFNSPIHK IYKGISRNKD   350
SDSEKREVLR NISINANHAD NLLQQENKRL KRSLDDAITN ENINSKNLEV   400
FYHRPAPKPP VTKKVEIVEP AKSASLSNNR NIITVNDSQY EKIELLGRGG   450
SSRVYKVKGS GNRVYALKRV SFDAFDDSSI DGFKGEIELL EKLKDQKRVI   500
QLLDYEMGDG LLYLIMECGD HDLSQILNQR SGMPLDFNFV RFYTKEMLLC   550
IKVVHDAGIV HSDLKPANFV LVKGILKIID FGIANAVPEH TVNIYRETQI   600
GTPNYMAPEA LVAMNYTQNS ENQHEGNKWK VGRPSDMWSC GCIIYQMIYG   650
KPPYGSFQGQ NRLLAIMNPD VKIPFPEHTS NNEKIPKSAI ELMKACLYRN   700
PDKRWTVDKV LSSTFLQPFM ISGSIMEDLI RNAVRYGSEK PHISQDDLND   750
VVDTVLRKFA DYKI                                          764