SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameMKS1
Systematic nameYNL076W
AliasLYS80
DescriptionNegative regulator of RAS-cAMP pathway

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1 MULTI RINGSCFGRR1   
* Blank: not determined, NA: not applicable.

References
[1]EvidenceUb-conjugate Confirmation
MethodWestern blot
Reference"A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1."
Liu Z, Spirek M, Thornton J, Butow RA.
Mol Biol Cell. 16(10):4893-904 (2005) [16093347]

Cross References
Swiss-Prot accessionP34072
SGD YNL076W
Gene Ontology (GO)
Cellular componentGO:0005622intracellularIC:SGD.
Molecular functionGO:0016564transcriptional repressor activityIDA:SGD.
Biological processGO:0031930mitochondrial signaling pathwayIPI:SGD.
Biological processGO:0006808regulation of nitrogen utilizationIMP:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)
Residue indexType
164Phosphoserine.
247Phosphoserine.
264Phosphoserine.
442Phosphoserine.
518Phosphoserine, by PKA (Potential).

Sequence Information
Sequence length584
Molecular weight65643

	---------+----------+----------+----------+----------+
MSREAFDVPN IGTNKFLKVT PNLFTPERLN LFDDVELYLT LIKASKCVEQ   50
GERLHNISWR ILNKAVLKEH NINRSKKRDG VKNIYYVLNP NNKQPIKPKQ   100
AAVKQPPLQK ANLPPTTAKQ NVLTRPMTSP AIAQGAHDRS LDNPNSTNND   150
VKNDVAPNRQ FSKSTTSGLF SNFADKYQKM KNVNHVANKE EPQTIITGFD   200
TSTVITKKPL QSRRSRSPFQ HIGDMNMNCI DNETSKSTSP TLENMGSRKS   250
SFPQKESLFG RPRSYKNDQN GQLSLSKTSS RKGKNKIFFS SEDEDSDWDS   300
VSNDSEFYAD EDDEEYDDYN EEEADQYYRR QWDKLLFAKN QQNLDSTKSS   350
VSSANTINSN TSHDPVRKSL LSGLFLSEAN SNSNNHNTAH SEYASKHVSP   400
TPQSSHSNIG PQPQQNPPSA NGIKQQKPSL KTSNVTALAS LSPPQPSNNE   450
RLSMDIQKDF KTDNESNHLY ESNAPLTAQT ILPTALSTHM FLPNNIHQQR   500
MAIATGSNTR HRFSRRQSMD IPSKNRNTGF LKTRMEISEE EKMVRTISRL   550
DNTSIANSNG NGNDDTSNQR TEALGRKTSN GGRI                    584