SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameIZH3
Systematic nameYLR023C
DescriptionADIPOR-like receptor IZH3

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1 MULTI    RPN10 Proteasomal Degradation
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (ubiquitin-chain by UBA domain-containing protein, 6xHis-ubiquitin (two-step)), LC/MS, validation (statistical quantitative analysis)
Reference"Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway."
Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ.
Mol Cell Proteomics. 6(11):1885-95 (2007) [17644757]

Cross References
Swiss-Prot accessionQ07959
SGD YLR023C
Gene Ontology (GO)
Cellular componentGO:0005783endoplasmic reticulumIDA:SGD.
Cellular componentGO:0016020membraneTAS:SGD.
Biological processGO:0006629lipid metabolic processTAS:SGD.
Biological processGO:0006882zinc ion homeostasisIMP:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length543
Molecular weight62571

	---------+----------+----------+----------+----------+
MMDSSSKSLT QYIPSPMGSL SRLKQKGVDN FQKVKKSGKS IYNYNYSKFV   50
PHPFSTIDES VKHSESGRYD DLEIIRPTKE KEVTSSVYKR NSGKSLNTES   100
QFSLGDSDAA TLVNSVATFK LNNASTSTSL VSSSSTVCSQ AKSSLRSPTS   150
RLNDTKIKEE NNYISSVKDY CGPMRKSMVK TEILIEEPLN PTTDIKSFIN   200
SYNHGKAYSL GETQHLHYYQ LPFPWRENRY IIHGYRFYNT HSKSLLSIFN   250
WYGWHNETSN IWSHLLGAIY IIYLAIYDFP QSEVWRNSQV PPQARWIVFM   300
FLAAALKCML SSVFWHTFNG TSFLKLRSKF ACVDYSGITI LITASILTTE   350
FVTMYSCYWA MYTYMSISLA LGVFGVFMNW SPRFDRPEAR PLRIRFFILL   400
ATMGVLSFLH LIFLTDLHYA ATLFSPVTYK SVVWYLVGVV FYGSFIPERF   450
RSDVQVDKTI PTNYELSTDL EIITKQREIH FREVPTAHSK CSSCPSHAKS   500
FKSLWWVDYF GCSHTFWHFF VVLGVIGHYR AILDMFAKRW ILS          543