SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameIME2
Systematic nameYJL106W
AliasSME1
DescriptionMeiosis induction protein kinase IME2/SME1

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1  CDC34RINGSCFGRR1   
* Blank: not determined, NA: not applicable.

References
[1]EvidenceUb-conjugate Confirmation
MethodWestern blot
Reference"Glucose inhibits meiotic DNA replication through SCFGrr1p-dependent destruction of Ime2p kinase."
Purnapatre K, Gray M, Piccirillo S, Honigberg SM.
Mol Cell Biol. 25(1):440-50 (2005) [15601864]

Cross References
Swiss-Prot accessionP32581
SGD YJL106W
Gene Ontology (GO)
Cellular componentGO:0005634nucleusIDA:SGD.
Molecular functionGO:0004672protein kinase activityIDA:SGD.
Biological processGO:0006468protein amino acid phosphorylationTAS:SGD.
Biological processGO:0040020regulation of meiosisIMP:SGD.
EC number 2.7.11.1

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length645
Molecular weight73593

	---------+----------+----------+----------+----------+
MVEKRSRQSS SSGSEFSVPP DVDNPPLSIP LKTLSDRYQL IEKLGAGSFG   50
CVTLAKAQFP LSNILGKQHD IRGTLMDQPK NGHQNYITKT QGVVAIKTMM   100
TKLHTLQDYT RVREIKFILA IPANDHLIQI FEVFIDSENY QLHIVMECME   150
QNLYQMMKHR RRRVFSIPSL KSILSQILAG LKHIHEHNFF HRDLKPENIL   200
ITPSTQYFEK EYMNQIGYQD NYVIKLADFG LARHVENKNP YTAYVSTRWY   250
RSPEILLRSG YYSKPLDIWA FGCVAVEVTV FRALFPGANE IDQIWKILEV   300
LGTPIKRSDF VNTNHITAPP PGGFWDDASN LVHKLNLKLP YVEGSSLDHL   350
LSSSQLSDLS EVVKKCLRWD PNERATAQEL CEMPFFENTV ASQVDARGNV   400
TNTEQALIFA GINPVATNTK PIYFNSSTKL PAETESNDID ISNNDHDSHA   450
MCSPTLNQEK LTLVEFLNEF VEEDNDDHSI PDVGTDSTIS DSIDETELSK   500
EIRNNLALCQ LPDEEVLDHS LSNIRQLTND IEIINKDEAD NMEQLFFDLE   550
IPEKDEFQRK QPFNEHADID EDIVLPYVNN SNYTHTDRSH HRGDNVLGDA   600
SLGDSFNSMP DFTPRNFLIP TLKKSREKFE PHLSNSNQHF GNVTF        645