SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameHAC1
Systematic nameYFL031W
AliasERN4, IRE15, IRE2
DescriptionTranscriptional activator HAC1

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1  CDC34RINGSCFCDC4  Proteasomal Degradation
* Blank: not determined, NA: not applicable.

References
[1]EvidenceProtein Stability Assay
MethodWestern blot
Reference"SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae."
Pal B, Chan NC, Helfenbaum L, Tan K, Tansey WP, Gething MJ.
Mol Biol Cell. 18(2):426-40 (2007) [17108329]

Cross References
Swiss-Prot accessionP41546
SGD YFL031W
Gene Ontology (GO)
Cellular componentGO:0005634nucleusIDA:SGD.
Molecular functionGO:0003704specific RNA polymerase II transcription fa...TAS:SGD.
Molecular functionGO:0003700transcription factor activityIDA:SGD.
Biological processGO:0006644phospholipid metabolic processTAS:SGD.
Biological processGO:0006990unfolded protein response, positive regulat...IMP:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length238
Molecular weight26905

	---------+----------+----------+----------+----------+
MEMTDFELTS NSQSNLAIPT NFKSTLPPRK RAKTKEEKEQ RRIERILRNR   50
RAAHQSREKK RLHLQYLERK CSLLENLLNS VNLEKLADHE DALTCSHDAF   100
VASLDEYRDF QSTRGASLDT RASSHSSSDT FTPSPLNCTM EPATLSPKSM   150
RDSASDQETS WELQMFKTEN VPESTTLPAV DNNNLFDAVA SPLADPLCDD   200
IAGNSLPFDN SIDLDNWRNP EAQSGLNSFE LNDFFITS                238