SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameGND1
Systematic nameYHR183W
Description6-phosphogluconate dehydrogenase, decarboxylating 1

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1        Proteasomal Degradation
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (ubiquitin-chain by UBA domain-containing protein, 6xHis-ubiquitin (two-step)), LC/MS, validation (statistical quantitative analysis)
Reference"Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway."
Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ.
Mol Cell Proteomics. 6(11):1885-95 (2007) [17644757]

Cross References
Swiss-Prot accessionP38720
SGD YHR183W
Gene Ontology (GO)
Cellular componentGO:0005739mitochondrionIDA:SGD.
Molecular functionGO:0004616phosphogluconate dehydrogenase (decarboxyla...IMP:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Biological processGO:0009051pentose-phosphate shunt, oxidative branchIGI:SGD.
Biological processGO:0006979response to oxidative stressIMP:SGD.
EC number 1.1.1.44

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length489
Molecular weight53543

	---------+----------+----------+----------+----------+
MSADFGLIGL AVMGQNLILN AADHGFTVCA YNRTQSKVDH FLANEAKGKS   50
IIGATSIEDF ISKLKRPRKV MLLVKAGAPV DALINQIVPL LEKGDIIIDG   100
GNSHFPDSNR RYEELKKKGI LFVGSGVSGG EEGARYGPSL MPGGSEEAWP   150
HIKNIFQSIS AKSDGEPCCE WVGPAGAGHY VKMVHNGIEY GDMQLICEAY   200
DIMKRLGGFT DKEISDVFAK WNNGVLDSFL VEITRDILKF DDVDGKPLVE   250
KIMDTAGQKG TGKWTAINAL DLGMPVTLIG EAVFARCLSA LKNERIRASK   300
VLPGPEVPKD AVKDREQFVD DLEQALYASK IISYAQGFML IREAAATYGW   350
KLNNPAIALM WRGGCIIRSV FLGQITKAYR EEPDLENLLF NKFFADAVTK   400
AQSGWRKSIA LATTYGIPTP AFSTALSFYD GYRSERLPAN LLQAQRDYFG   450
AHTFRVLPEC ASDNLPVDKD IHINWTGHGG NVSSSTYQA               489