SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameCTK1
Systematic nameYKL139W
DescriptionCTD kinase subunit alpha

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1         
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (6xHis-Myc-ubiquitin), LC/MS, validation (virtual Western blot)
Reference"Systematic approach for validating the ubiquitinated proteome."
Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
Anal Chem. 80(11):4161-9 (2008) [18433149]

Cross References
Swiss-Prot accessionQ03957
SGD YKL139W
Gene Ontology (GO)
Cellular componentGO:0032806carboxy-terminal domain protein kinase complexIPI:SGD.
Molecular functionGO:0004693cyclin-dependent protein kinase activityIDA:SGD.
Molecular functionGO:0005515protein bindingIPI:IntAct.
Biological processGO:0031124mRNA 3'-end processingIGI:SGD.
Biological processGO:0032786positive regulation of RNA elongationIDA:SGD.
Biological processGO:0006468protein amino acid phosphorylationIMP:SGD.
Biological processGO:0000723telomere maintenanceIMP:SGD.
EC number 2.7.11.23

Additional Features
Other Post Translational Modifications (PTM)
Residue indexType
14Phosphoserine, by autocatalysis (By
26Phosphoserine.

Sequence Information
Sequence length528
Molecular weight60501

	---------+----------+----------+----------+----------+
MSYNNGNTYS KSYSRNNKRP LFGKRSPNPQ SLARPPPPKR IRTDSGYQSN   50
MDNISSHRVN SNDQPGHTKS RGNNNLSRYN DTSFQTSSRY QGSRYNNNNT   100
SYENRPKSIK RDETKAEFLS HLPKGPKSVE KSRYNNSSNT SNDIKNGYHA   150
SKYYNHKGQE GRSVIAKKVP VSVLTQQRST SVYLRIMQVG EGTYGKVYKA   200
KNTNTEKLVA LKKLRLQGER EGFPITSIRE IKLLQSFDHP NVSTIKEIMV   250
ESQKTVYMIF EYADNDLSGL LLNKEVQISH SQCKHLFKQL LLGMEYLHDN   300
KILHRDVKGS NILIDNQGNL KITDFGLARK MNSRADYTNR VITLWYRPPE   350
LLLGTTNYGT EVDMWGCGCL LVELFNKTAI FQGSNELEQI ESIFKIMGTP   400
TINSWPTLYD MPWFFMIMPQ QTTKYVNNFS EKFKSVLPSS KCLQLAINLL   450
CYDQTKRFSA TEALQSDYFK EEPKPEPLVL DGLVSCHEYE VKLARKQKRP   500
NILSTNTNNK GNGNSNNNNN NNNDDDDK                           528