SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameCRM1
Systematic nameYGR218W
AliasKAP124, XPO1
DescriptionExportin-1

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1 MULTI       
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (ubiquitin-chain by UBA domain-containing protein, 6xHis-ubiquitin (two-step)), LC/MS
Reference"Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets."
Mayor T, Lipford JR, Graumann J, Smith GT, Deshaies RJ.
Mol Cell Proteomics. 4(6):741-51 (2005) [15699485]

Cross References
Swiss-Prot accessionP30822
SGD YGR218W
Gene Ontology (GO)
Cellular componentGO:0005634nucleusIDA:SGD.
Molecular functionGO:0008320protein carrier activityIDA:SGD.
Biological processGO:0006406mRNA export from nucleusIMP:SGD.
Biological processGO:0000055ribosomal large subunit export from nucleusIMP:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length1084
Molecular weight124104

	---------+----------+----------+----------+----------+
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK   50
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS   100
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN   150
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV   200
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA   250
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT   300
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL   350
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST   400
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE   450
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW   500
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV   550
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI   600
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI   650
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA   700
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA   750
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM   800
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT   850
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV   900
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS   950
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS   1000
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL   1050
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD                    1084