SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameCOS3
Systematic nameYML132W
DescriptionProtein COS2/COS3

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1K18;K205        
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (6xHis-Myc-ubiquitin), LC/MS
Reference"A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
Hitchcock AL, Auld K, Gygi SP, Silver PA.
Proc Natl Acad Sci U S A. 100(22):12735-40 (2003) [14557538]

Cross References
Swiss-Prot accessionP38363
SGD YML132W
Gene Ontology (GO)
Cellular componentGO:0005624membrane fractionIDA:SGD.
Cellular componentGO:0000324vacuole, cell cycle-correlated morphologyIDA:SGD.
Molecular functionGO:0005515protein bindingIMP:SGD.
Biological processGO:0006883sodium ion homeostasisIMP:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)  

Sequence Information
Sequence length379
Molecular weight45165

	---------+----------+----------+----------+----------+
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR   50
IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS   100
KQLIQFCKEI TENTPSSDPH DWEVVAANLN SYLYENNVWN TKYFFFNAMV   150
CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV PYIEEALGVY FTEVEKQWKL   200
FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY   250
VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE   300
SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK   350
KSMWPLPLNV ELWPYIKEAQ LSRSEVLLV                          379

	* Ubiquitinated lysine is denoted as red color.