SCUD (Saccharomyces Cerevisiae Ubiquitination Database)


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Substrate Information

General Information
Standard nameCDC37
Systematic nameYDR168W
AliasSMO1
DescriptionHsp90 co-chaperone Cdc37

Ubiquitination Features
NumberSiteTypeE2E3 ClassE3 SubclassSubstrate ReceptorUbiquitin ReceptorDUBEffect
1         
* Blank: not determined, NA: not applicable.

References
[1]EvidencePurification & Protein ID
Methodpurification (6xHis-Myc-ubiquitin), LC/MS, validation (virtual Western blot)
Reference"Systematic approach for validating the ubiquitinated proteome."
Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
Anal Chem. 80(11):4161-9 (2008) [18433149]

Cross References
Swiss-Prot accessionP06101
SGD YDR168W
Gene Ontology (GO)
Cellular componentGO:0005737cytoplasmIDA:SGD.
Molecular functionGO:0042802identical protein bindingIPI:IntAct.
Molecular functionGO:0051082unfolded protein bindingIDA:SGD.
Biological processGO:0000161MAPKKK cascade during osmolarity sensingIMP:SGD.
Biological processGO:0050821protein stabilizationIMP:SGD.
Biological processGO:0000074regulation of progression through cell cycleIMP:SGD.
Biological processGO:0032872regulation of stress-activated MAPK cascadeIMP:SGD.
Biological processGO:0007103spindle pole body duplication in nuclear en...IGI:SGD.
EC number  

Additional Features
Other Post Translational Modifications (PTM)
Residue indexType
14Phosphoserine.
17Phosphoserine.
367Phosphoserine.

Sequence Information
Sequence length506
Molecular weight58385

	---------+----------+----------+----------+----------+
MAIDYSKWDK IELSDDSDVE VHPNVDKKSF IKWKQQSIHE QRFKRNQDIK   50
NLETQVDMYS HLNKRVDRIL SNLPESSLTD LPAVTKFLNA NFDKMEKSKG   100
ENVDPEIATY NEMVEDLFEQ LAKDLDKEGK DSKSPSLIRD AILKHRAKID   150
SVTVEAKKKL DELYKEKNAH ISSEDIHTGF DSSFMNKQKG GAKPLEATPS   200
EALSSAAESN ILNKLAKSSV PQTFIDFKDD PMKLAKETEE FGKISINEYS   250
KSQKFLLEHL PIISEQQKDA LMMKAFEYQL HGDDKMTLQV IHQSELMAYI   300
KEIYDMKKIP YLNPMELSNV INMFFEKVIF NKDKPMGKES FLRSVQEKFL   350
HIQKRSKILQ QEEMDESNAE GVETIQLKSL DDSTELEVNL PDFNSKDPEE   400
MKKVKVFKTL IPEKMQEAIM TKNLDNINKV FEDIPIEEAE KLLEVFNDID   450
IIGIKAILEN EKDFQSLKDQ YEQDHEDATM ENLSLNDRDG GGDNHEEVKH   500
TADTVD                                                   506